Health Through Happiness Consulting
h-t-h.com

  
 It is not only the most difficult thing to know oneself, but the most inconvenient one, too. ~H.W. Shaw

 

 

Depression: My Journey

      Both conditions are normal and are experienced by most people in response to painful life events.  If someone close dies, for example, the person will experience temporary depression as a part of a grieving process.  Most celebrities admit to feeling apprehensive every time before an on-stage performance, which can be called anxiety.  The difference lies in the fact that some people feel that way without any outside influence.  Of course, many of us had hurtful pasts, but normally the resulting depression should not linger.    There is ‘light at the end of the tunnel.’  When someone receives a diagnosis of depression or anxiety, they do not see the light.  They do not know what it is like not to be depressed.  Depression has become a way of life, part of their identity, a norm.  The same can be said about anxiety.  Since clinically depressed people do not know any better, they are actually functional members of society.  They work, attend college, get involved in relationships, have children.  They claim to be happy, to live normal lives.  Only a fraction of them seek help.  Sometimes it requires an ‘awakening’, such as a suicide attempt, a break-up; an unmanageable, incapacitating anxiety attack that results in a loss of a job.

     Believe it or not, depression and anxiety can be conquered.  It is possible to experience true happiness, the sense of bliss, the inner peace.  I can testify to that.  After suffering depression and anxiety for years, I finally got it beat.  It is an amazing feeling of freedom.  It is the feeling of lead weight lifting, the pain not being a part of normal existence anymore.  I gained the ability to enjoy sunsets, breakfasts at a small diner, flowers, and other simple things.  The sky turned blue, the grass turned green.

     The fight was not easy.  Sometimes I thought I would never get there.  Now when I feel depressed, it surprises me.  I actually forgot how devastating my depression was.  I forgot about staying home, not having friends, and trying to take my own life.  I feel happier and healthier now than when I was a teenager.

Let me share with you what I learned through my difficult journey.

     Depression and anxiety are partially chemical, partially psychological.  I personally believe in ‘doing it the easy way.’  It is easier to correct the chemical imbalance first, and then work on other issues such as history of childhood trauma.  Also, all the years I was trying to fix myself and eventually other people, I found that a huge number of health problems can be blamed on just two things: nutritional deficiencies and psychological trauma, no matter how minor.  The nutritional deficiencies make recovery from trauma extremely difficult, and therefore should be corrected first.

     Many studies are done on the subject of depression.  Antidepressant prescription drugs flood the market.  The counselors are in high demand.  Many alternatives are available as well.  I would like to inform you about some options.  I will have to write an encyclopedia to cover all possibilities, so I would like to stick with simple, inexpensive, and readily available therapies.

     First and foremost, you have to realize that depression and anxiety come from within.  No therapist can get inside your head and ‘tighten the loose screws.’  You are fully responsible for doing the work of turning the screws, the therapist merely hands you the screwdriver.

     One of the turning points for me (other than a desire to get better) was fish oil.  A doctor recommended I take fish oil for acne, and it had a ‘side effect’ of making me feel better.  Fish oil contains omega-3 fatty acids.  They are needed, but not made by the body.  Every cell in our bodies has a membrane, which contains and separates the cells from each other.  Cells are soft, pliable entities that change their shape if necessary.  When they are a part of an organ such as liver, it is more difficult, but immune system cells flow freely and change their shapes more readily.  The membranes contain receptors-structures allowing cell communication.  Unlike you and me, they cannot talk, so they ‘talk’ to each other and the outside world through those receptors.  If the membrane is too rigid, the receptors get ‘squeezed’ and sometimes deformed, which affects ‘cell talk.’  This is where omega-3’s come in.  They wedge themselves between other structures of cell membranes, making them pliable, allowing the receptors to float freely within the membrane.  Another substance that has the same effect is cholesterol.  No surprise that numerous studies found low omega-3 fatty acid and cholesterol levels among people with mental illnesses, especially depression. 1-12

      From my personal and professional experience, a person should get about 3,000mg of omega-3 fatty acids per day.13, 14 Eating fish definitely helps.  Keep in mind that most fish, especially large ones, contain high levels of mercury-a deadly heavy metal.  There are other heavy metals as well, such as arsenic and lead.  Different species of fish have different amounts of different metals.  Truly choosing the least of all evils.  Even developing countries have contaminated fish, as the entire planet seems to be plaqued.15-19 Personally, I eat fish occasionally, so I take supplements.  Most of them contain few hundred milligrams, and you will have to take twenty pills a day to achieve the high dose.  Currently I take GNC Double Strength Fish Body Oil, four soft gels per day.  Keep in mind that fish oil is a blood thinner, so if you start bruising easily, decrease the dose.20-22  Most people burp it up.  I find it worth the benefits, but if you have hard time keeping them down, take fish oil pills in the middle of the meal, so that the weight of food keeps it down.  Also, taking it with digestive enzymes, particularly lipase, and lecithin helps with burping.  Very low dose fish oil is available in enteric coated form.23  In the worst case scenario eat walnuts-they are rich in omega-3’s.24  If you are not taking fish oil, but rather an omega-3 supplement, make sure to take vitamin E with it.  Regular fish oil contains it, but omega-3 capsules do not, resulting in depletion of vitamin E from the tissues.25  Four hundred units is an average amount, but it is another blood thinner, so keep an eye on bruising.

   It is very difficult to raise cholesterol.  Low cholesterol is indicated by a blood test below 150-160mg/dL.  There are conflicting studies on diet and cholesterol, as the levels are also affected by one’s genes.  The general agreement is that low fat diet lowers cholesterol.26-31 Another option is coconut oil, which normalizes cholesterol levels by either raising or lowering it.32, 33 I take it myself.  Coconut oil is a fat, and its digestion is impaired by low cholesterol, so I take digestive enzymes with it.  It should be taken in divided doses, preferably one tablespoon 2-4 times daily.  Best if taken with food, it is also available in capsules.  If you have gallbladder stones-be very careful as it might precipitate an attack.34 Gallbladder makes the bile to digest fats, and coconut oil is a fat.  Bile is made mainly of cholesterol, so you can see how all things are connected.  Cholesterol is made by the liver-take care of your liver.35 One of the simplest things is to drink diluted lemon juice.36-38 Coconut oil and fish oil also help the liver.  They are powerful multi-tasking oils.  Individuals with advanced liver damage due to alcohol need to exercise care with fish oil supplements.39-43

     Another helpful supplement is magnesium.  Nowadays, it is virtually impossible to get enough magnesium from the diet.  It comes mainly from vegetables, but the way they are grown today depletes them of this mineral.  Magnesium makes the nervous system less excitable.  That is why it also helps with decreasing pain and blood pressure.  It also relieves constipation and muscle spasms.  There is more as magnesium participates in hundreds of reactions, but it is outside the scope of this discussion.  Magnesium will be very helpful with anxiety, as it will help calm you down.  Magnesium deficiency has also been found in people with mental problems.  Potential side effect is diarrhea (decrease the dose as needed).  Generally you should take 300-1,000mg per day.44, 45

     As most of you already know, majority of prescriptions are targeting serotonin receptors.  Serotonin is a neurotransmitter, or ‘a spoken word’ produced by one cell and ‘heard’ by another.  Some people do not make enough serotonin, and others have cells that do not understand the message.  Serotonin reuptake inhibitors act like a hearing aid.  So they can only help people who make serotonin.  Also, those drugs have been shown to cause people to commit suicide among other side effects.  I have tried them myself without any success.  So I would like to address the people who do not make enough serotonin.  You may be deficient in the building materials-amino acid called tryptophan.  The body converts it into melatonin, which helps you sleep, and when you wake up, the sunlight helps convert melatonin into serotonin.  Conclusion:  get some sunlight (or artificial bright light) first thing upon awakening.  It is a simple and extremely effective approach.  Also, you can take tryptophan at night, or you can eat turkey (now you know why everybody gets sleepy after Thanksgiving dinner-all that tryptophan in the turkey). 46-48 Aside from sunlight, the body needs carbohydrates for the production of serotonin-hence the cravings.  I do not advocate high carb diet, but moderate intake at the same time as tryptophan, combined with sunlight exposure first thing in the morning is just what the doctor ordered.  Also, you can take melatonin supplements, adjusting the dose carefully as it might be too much if you are young.  Melatonin production declines with age in most people.49

     To help melatonin work properly, you also need vitamin B12 (aka methylcobalamin or cyanocobalamin-its two forms). 50 B12 deficiency has been found in a wide range of health problems, especially those involving the nervous system.  It has been shown to be safe if taken in very high doses, up to tens of milligrams (normally sold in micrograms-there are a thousand micrograms in a milligram).  Definitely depression and lethargy have been associated with B12 deficiency.  It comes mainly from animal sources, so vegetarians are notoriously deficient unless they take supplements.  I would suggest 1-5 mg per day for most depressed people.  If you have digestion problems, the vitamin (or any other supplement for that matter) would not be absorbed well.  Therefore, sublingual form is the best choice.  It does not taste bad, and you can think of it as a hard candy.  It is best to take B vitamins in combination; so adding folic acid and B6 would be another step in fighting depression.  Everything is connected in the body, and frequently the deficiency of one element is compensated by another, resulting in its deficiency.51 Be extremely careful with B6 as its overdose can cause permanent nervous damage!  About 75 mg per day is a low dose, but it is safe.  However, B6 is needed for the production of serotonin, so its deficiency can cause depression.  The safest approach is to measure blood levels if doses over 75 mg per day are desired or required.52

          Hormone imbalances are no question a part of depression, especially the sex hormones.  Both men and women make estrogen, progesterone, and testosterone, but in different proportions.  The imbalance of those ratios has detrimental effects.  Men and women deficient in testosterone have been found to be depressed.53-56 Hormone testing and balancing are highly recommended, but not always accessible and affordable.  I was amazed at how much it helped me.  I was a wreck around my period (worse than other times), had no stamina, or motivation.  Over the course of hormone balancing I halved the estrogen, doubled the testosterone, and raised progesterone ten times from the original test.  I am no longer depressed.  I put on five pounds of muscle without working out, my acne cleared dramatically, I increased my stamina, and my heart palpitations went away, even though I had abnormal heart readings since I was ten years old.  I have worked with a large number of people balancing their hormones with remarkable outcomes.  Anything from erectile dysfunction, depression, diabetes, menopause to weight loss.  If you are on a birth control pill, it may actually further imbalance your hormones, making your depression worse (however, in some cases it may make it better).  You have to be very careful with hormones as their imbalance causes cancers.57-59 Now, the part about cholesterol as discussed earlier: sex hormones are made out of cholesterol, so lack of cholesterol causes hormonal deficiencies, resulting in all kinds of problems (including cancer). 60-61 Melatonin regulates sex hormones, so its deficiency or overproduction can create serious problems as well.62-64

      There are still more supplements you can take, but simplest solution is usually the correct one.

     After searching for years, I found a handful of simple and quick techniques.  When I started battling my depression, the hardest part was to force myself to do the right things.  Yes, meditation, exercise, yoga, socializing all have a great effect, but doing them was a chore.  I would start and stop exercise programs, I could only meditate in yoga classes, and socializing was the hardest part.  I also have a mild case of attention deficit, so anything taking longer then ten minutes was beyond my attention span.  So I started with supplements.

     My next recommended step will be getting sunlight every morning-safe and cheap.  In combination with the sunlight, do simple stretching, feel your spine align itself, and think about something pleasant.  Smile.  Even if you feel blue, smile.   Studies show that physically smiling will actually make you feel better.65, 66 Also, find a feature that you like about yourself-your eyes, hair, your whole body maybe, the fact that you speak two languages-anything.  Later, find more and more features as your depression and anxiety let go.  Remember-it is a multi-step process.  You are going to be like a baby learning to walk.

     Once that becomes a routine-all of one minute, you can attempt short periods (up to 5-10 minutes) of meditation.  Meditation is not thinking in words.  It is very difficult at first, but in itself it is very rewarding.  I also find it extremely energizing.  I feel like a ‘recharged battery’ afterwards.  Of course, there is an ultimate goal of enlightenment, but you can learn about that from numerous meditation books and CD’s.

     Then add exercise-five minutes at a time, mainly gentle stretching.  Increase the time and complicate the routine as you go.  Studies show that moderate exercise will increase testosterone, very heavy exercise will lower it.67-70

     Doing a little bit is better than doing nothing.  Two-minute exercise routine will lower your depression versus no exercise at all.  I speak from knowledge and personal experience.  Now smile. 

     The one thing that you can do at any time is Emotional Freedom Technique.  It involves rubbing or tapping certain points on the face, hands, and upper body.  The concept comes from Eastern medicine and involves acupuncture points.  I personally found it to be extremely effective.  It takes seconds to minutes, depending on the number of points rubbed.  In some cases it provides immediate relief.

     The procedure requires that you either think about the underlying problem or something pleasant that you want to accomplish while tapping or rubbing the points.  The website suggests the following, “Even though [state the problem], I deeply and completely accept myself.”  I found that no particular phrase is a better choice, however, consistency helps.

     The list of ‘spots’: where the nose and eyebrow meet, outer corner of the eye, under the eye, between nose and lips, under lips-above the chin, meeting point of breast and collar bones, under arm, under a nipple, side of fingertips of thumb, index, middle fingers, and pinky.  They should feel a little sore because many nerve endings come to meet at those points.  Once you feel pain-you found it!  Rub it gently, just enough to make it ‘hurt so good’.  You can do one or several spots, rub as long or as little as you want.  Find what works for you.  I found that spot under my eyes worked the best, but for some they would not, so experiment.  If you had trauma in the past-you were molested as a child, mentally or emotionally abused by your family, raped as an adult, you are an orphan and or grew up in foster homes-think about those events while tapping the points.  Do not relive them to the point of retraumatizing yourself, just think about them.  Many times they actually let go.71

     In conclusion: I am nothing more that an educator.  I only provide information, which you can use to your benefit or harm.  If you take something you are not deficient in, you would very likely get worse.  Supplements are as strong as prescriptions (contrary to popular belief), so be careful.  You may be allergic to any or all of the supplements described.  Do research; educate yourself, but most importantly-get in touch with your body.  It will tell you what it needs, it always had, but you never listened.  Listen now.  And smile.  Do not take any supplements without discussing them with your doctor, especially if you are taking prescriptions, as the interactions can be devastating.

There is light at the end of the tunnel.  You are so far down now that the only way for you is up. 

References: 

  1. McNamara RK, Hahn CG, Jandacek R, Rider T, Tso P, Stanford KE, Richtand NM.  Selective Deficits in the Omega-3 Fatty Acid Docosahexaenoic Acid in the Postmortem Orbitofrontal Cortex of Patients with Major Depressive Disorder. Biol Psychiatry. 2006 Dec 21.

  2. Osher Y, Belmaker RH, Nemets B. Clinical trials of PUFAs in depression: State of the art.World J Biol Psychiatry. 2006;7(4):223-30.

  1. Ross BM. omega-3 Fatty acid deficiency in major depressive disorder is caused by the interaction between diet and a genetically determined abnormality in phospholipid metabolism.  Med Hypotheses. 2006 Oct 11; [Epub ahead of print]

4.     Reis LC, Hibbeln JR. Cultural symbolism of fish and the psychotropic properties of omega-3 fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov;75(4-5):227-36. Epub 2006 Sep 7.

5.     McNamara RK, Carlson SE. Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology. Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov;75(4-5):329-49. Epub 2006 Sep 1.

6.     Sublette ME, Hibbeln JR, Galfalvy H, Oquendo MA, Mann JJ. Omega-3 polyunsaturated essential fatty acid status as a predictor of future suicide risk. Am J Psychiatry. 2006 Jun;163(6):1100-2.

7.     Carrillo-Tripp M, Feller SE. Evidence for a mechanism by which omega-3 polyunsaturated lipids may affect membrane protein function. Biochemistry. 2005 Aug 2;44(30):10164-9.

8.     Sarchiapone M, Roy A, Camardese G, De Risio S. Further evidence for low serum cholesterol and suicidal behaviour.  J Affect Disord. 2000 Dec;61(1-2):69-71.

9.     Glueck CJ, Tieger M, Kunkel R, Hamer T, Tracy T, Speirs J. Hypocholesterolemia and affective disorders. Am J Med Sci. 1994 Oct;308(4):218-25.

10.   Atmaca M, Kuloglu M, Tezcan E, Ustundag B, Bayik Y.    Serum leptin and cholesterol levels in patients with bipolar disorder. Neuropsychobiology. 2002;46(4):176-9.

11.  Cassidy F, Carroll BJ. Hypocholesterolemia during mixed manic episodes. Eur Arch Psychiatry Clin Neurosci. 2002 Jun;252(3):110-4.

12.  Rabe-Jablonska J, Poprawska I. Levels of serum total cholesterol and LDL-cholesterol in patients with major depression in acute period and remission. Med Sci Monit. 2000 May-Jun;6(3):539-47.

13.  Cazzola R, Russo-Volpe S, Miles EA, Rees D, Banerjee T, Roynette CE, Wells SJ, Goua M, Wahle KW, Calder PC, Cestaro B. Age- and dose-dependent effects of an eicosapentaenoic acid-rich oil on cardiovascular risk factors in healthy male subjects. Atherosclerosis. 2006 Jul 29; [Epub ahead of print]

14.  Arterburn LM, Hall EB, Oken H. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr. 2006 Jun;83(6 Suppl):1467S-1476S

15.  Passos CJ, Mergler D, Lemire M, Fillion M, Guimaraes JR. Fish consumption and bioindicators of inorganic mercury exposure. Sci Total Environ. 2006 Dec 29; [Epub ahead of print].

16.   Bjornberg KA, Vahter M, Grawe KP, Berglund M. Methyl mercury exposure in Swedish women with high fish consumption. Sci Total Environ. 2005 Apr 1;341(1-3):45-52.

17.  Mozaffarian D, Rimm EB. Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA. 2006 Oct 18;296(15):1885-99.

18.  Burger J, Stern AH, Gochfeld M. Mercury in commercial fish: optimizing individual choices to reduce risk. Environ Health Perspect. 2005 Mar;113(3):266-71.

19.  Falco G, Llobet JM, Bocio A, Domingo JL. Daily intake of arsenic, cadmium, mercury, and lead by consumption of edible marine species. J Agric Food Chem. 2006 Aug 9;54(16):6106-12.

20.  Vanschoonbeek K, Feijge MA, Paquay M, Rosing J, Saris W, Kluft C, Giesen PL, de Maat MP, Heemskerk JW. Variable hypocoagulant effect of fish oil intake in humans: modulation of fibrinogen level and thrombin generation. Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1734-40. Epub 2004 Jun 24.

21.  Hellsten G, Boman K, Saarem K, Hallmans G, Nilsson TK. Effects on fibrinolytic activity of corn oil and a fish oil preparation enriched with omega-3-polyunsaturated fatty acids in a long-term study. Curr Med Res Opin. 1993;13(3):133-9.

22.  Nieuwenhuys CM, Feijge MA, Vermeer C, Hennissen AH, Beguin S, Heemskerk JW. Vitamin K-dependent and vitamin K-independent hypocoagulant effects of dietary fish oil in rats. Thromb Res. 2001 Oct 15;104(2):137-47.

23.  FishSMART product description. 2007 Jan 5 http://www.health-n-energy.com/fishsmart.htm.

24.  Omega-3 Fatty Acid Content of Selected Foods. Minnesota Nutrient Data Base 4.04, Tufts University School of Medicine, Boston, MA
Revised 3/02
. http://www.tufts.edu/med/nutrition-infection/hiv/health_omega3.html.

25.  Turchetto E, Pignatti C. [Protection of essential fatty acids by vitamin E] Acta Vitaminol Enzymol. 1982;4(3):267-77. [Article in Italian].

26.  F. Glatz, P. R. Turner, M. B. Katan, A. F. Stalenhoef and B. Lewis.  Hypo- and hyperresponse of serum cholesterol level and low density lipoprotein production and degradation to dietary cholesterol in man. Annals of the New York Academy of Sciences, Vol 676, Issue 1 163-179.

27.   Strandhagen E, Zetterberg H, Aires N, Palmer M, Rymo L, Blennow K, Thelle DS. The apolipoprotein E polymorphism and the cholesterol-raising effect of coffee. Lipids Health Dis. 2004 Nov 30;3:26.

28.   Constant J. The role of eggs, margarines and fish oils in the nutritional management of coronary artery disease and strokes. Keio J Med. 2004 Sep;53(3):131-6.

29.  Caterm, Nilo B and Margo A Denke. January 2001 Behenic acid is a cholesterol-raising saturated fatty acid in humans. American Journal of Clinical Nutrition, v 73, No. 1, pp41-44.

30.   van Aalst-Cohen ES, Jansen AC, Tanck MW, Defesche JC, Trip MD, Lansberg PJ, Stalenhoef AF, Kastelein JJ. Diagnosing familial hypercholesterolaemia: the relevance of genetic testing. Eur Heart J. 2006 Sep;27(18):2240-6. Epub 2006 Jul 6.

31.  Viturro E, de Oya M, Lasuncion MA, Gorgojo L, Moreno JM, Benavente M, Cano B, Garces C. Cholesterol and saturated fat intake determine the effect of polymorphisms at ABCG5/ABCG8 genes on lipid levels in children. Genet Med. 2006 Sep;8(9):594-9.

32.  Nevin KG, Rajamohan T. Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation. Clin Biochem. 2004 Sep;37(9):830-5.

33.  Elson CE. Tropical oils: nutritional and scientific issues. Crit Rev Food Sci Nutr. 1992;31(1-2):79-102.

34.  Jonnalagadda SS, Trautwein EA, Hayes KC. Dietary fats rich in saturated fatty acids (12:0, 14:0, and 16:0) enhance gallstone formation relative to monounsaturated fat (18:1) in cholesterol-fed hamsters. Lipids. 1995 May;30(5):415-24.

35.  What is cholesterol? 2007 Jan 5 http://www.cholesterol-count.co.uk/.

36.  Miyake Y, Yamamoto K, Tsujihara N, Osawa T. Protective effects of lemon flavonoids on oxidative stress in diabetic rats. Lipids. 1998 Jul;33(7):689-95.

37.   Minato K, Miyake Y, Fukumoto S, Yamamoto K, Kato Y, Shimomura Y, Osawa T. Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver. Life Sci. 2003 Feb 21;72(14):1609-16.

38.  Ann Heustad, R.N. The Amazing Health Benefits of Drinking Lemon Water. Idaho Observer 2004 July.

39.   Charlton CP, Buchanan E, Holden CE, Preece MA, Green A, Booth IW, Tarlow MJ. Intensive enteral feeding in advanced cirrhosis: reversal of malnutrition without precipitation of hepatic encephalopathy. Arch Dis Child. 1992 May;67(5):603-7.

40.  Health Benefits of Virgin Coconut Oil - Liver Disease. 2007 Jan 5 http://www.virgincoconutoil.ca/virgin_coconut_oil_liver_disease.htm.

41.  Gonzalez-Periz A, Planaguma A, Gronert K, Miquel R, Lopez-Parra M, Titos E, Horrillo R, Ferre N, Deulofeu R, Arroyo V, Rodes J, Claria J. Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA. FASEB J. 2006 Dec;20(14):2537-9. Epub 2006 Oct 20.

42.  Capanni M, Calella F, Biagini MR, Genise S, Raimondi L, Bedogni G, Svegliati-Baroni G, Sofi F, Milani S, Abbate R, Surrenti C, Casini A. Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study. Aliment Pharmacol Ther. 2006 Apr 15;23(8):1143-51.

43.  Purohit V, Russo D, Coates PM. Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium. Alcohol. 2004 Aug;34(1):3-8.

44.  Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. : Med Hypotheses. 2006;67(2):362-70. Epub 2006 Mar 20.

45.  Scientific Abstracts: Comprehensive Nutrient Review: Magnesium Overview. 2007 Jan 5.  http://www.lef.org/abstracts/codex/magnesium_index.htm.

46.  Jon Zwayer. From Tryptophan to Serotonin to Melatonin. 2007 Jan 5. http://home.bluemarble.net/~heartcom/tryptophantoserotonintomelatonin.html

47.  Thilo Gambichler, Armin Bader, Mirjana Vojvodic, Falk G Bechara, Kirsten Sauermann, Peter Altmeyer, and Klaus Hoffmann. Impact of UVA exposure on psychological parameters and circulating serotonin and melatonin. BMC Dermatol. 2002; 2: 6.

48.  Antidepressant Medications for Children and Adolescents: Information for Parents and Caregivers. 2007 Jan 5. http://www.nimh.nih.gov/healthinformation/antidepressant_child.cfm.

49.  Melatonin. 2007 Jan 5.  http://www.umm.edu/altmed/ConsSupplements/Melatonincs.html.

50.  Mayer G, Kroger M, Meier-Ewert K. Effects of vitamin B12 on performance and circadian rhythm in normal subjects. Neuropsychopharmacology. 1996 Nov;15(5):456-64.

51.  2007 Jan 5. http://www.signaturesupplements.com/Research.htm.

52.  Vitamin B Deficiency: Megavitamin Therapy, Side Effects and Allergic Reactions 2007 Jan 5. http://www.holistichealthtopics.com/HMG/Bvitamin.html.

53.  McIntyre RS, Mancini D, Eisfeld BS, Soczynska JK, Grupp L, Konarski Z, Kennedy SH. Calculated bioavailable testosterone levels and depression in middle-aged men. Psychoneuroendocrinology. 2006 Oct;31(9):1029-35. Epub 2006 Sep 5.

54.  Markianos M, Tripodianakis J, Sarantidis D, Hatzimanolis J. Plasma testosterone and dehydroepiandrosterone sulfate in male and female patients with dysthymic disorder. Affect Disord. 2006 Dec 18; [Epub ahead of print].

55.  Wolkowitz OM, Reus VI, Keebler A, Nelson N, Friedland M, Brizendine L, Roberts E. Double-blind treatment of major depression with dehydroepiandrosterone. Am J Psychiatry. 1999 Apr;156(4):646-9.

56.  Schutter DJ, Peper JS, Koppeschaar HP, Kahn RS, van Honk J. Administration of testosterone increases functional connectivity in a cortico-cortical depression circuit. J Neuropsychiatry Clin Neurosci. 2005 Summer;17(3):372-7.

57.  Robinson SA, Dowell M, Pedulla D, McCauley L. Do the emotional side-effects of hormonal contraceptives come from pharmacologic or psychological mechanisms? Med Hypotheses. 2004;63(2):268-73.

58.  White E, Malone KE, Weiss NS, Daling JR. Breast cancer among young U.S. women in relation to oral contraceptive use. J Natl Cancer Inst. 1994 Apr 6;86(7):505-14.

59.  Lee J.R. Estrogen Dominance. 2007 Jan 11. http://www.johnleemd.com/store/estrogen_dom.html.

60.  Neaton JD, Blackburn H, Jacobs D, Kuller L, Lee DJ, Sherwin R, Shih J, Stamler J, Wentworth D. Serum cholesterol level and mortality findings for men screened in the Multiple Risk Factor Intervention Trial. Multiple Risk Factor Intervention Trial Research Group. Arch Intern Med. 1992 Jul;152(7):1490-500.

61.  Zureik M, Courbon D, Ducimetiere P. Decline in serum total cholesterol and the risk of death from cancer. Epidemiology. 1997 Mar;8(2):137-43.

62.  Adriaens I, Jacquet P, Cortvrindt R, Janssen K, Smitz J. Melatonin has dose-dependent effects on folliculogenesis, oocyte maturation capacity and steroidogenesis. Toxicology. 2006 Dec 7;228(2-3):333-43. Epub 2006 Oct 6.

63.  Schernhammer ES, Rosner B, Willett WC, Laden F, Colditz GA, Hankinson SE. Epidemiology of urinary melatonin in women and its relation to other hormones and night work. Cancer Epidemiol Biomarkers Prev. 2004 Jun;13(6):936-43.

64.  Silman R. Melatonin and the human gonadotrophin-releasing hormone pulse generator. J Endocrinol. 1991 Jan;128(1):7-11.

65.  VanSwearingen JM, Cohn JF, Bajaj-Luthra A. Specific impairment of smiling increases the severity of depressive symptoms in patients with facial neuromuscular disorders. Aesthetic Plast Surg. 1999 Nov-Dec;23(6):416-23.

66.  Read K.  What’s in a Smile? 2007 Jan 11. http://bipolar.about.com/cs/humor/a/000802_smile.htm.

67.  Maestu J, Jurimae J, Jurimae T. Hormonal response to maximal rowing before and after heavy increase in training volume in highly trained male rowers. J Sports Med Phys Fitness. 2005 Mar;45(1):121-6.

68.  Aizawa K, Akimoto T, Inoue H, Kimura F, Joo M, Murai F, Mesaki N. Resting serum dehydroepiandrosterone sulfate level increases after 8-week resistance training among young females. Eur J Appl Physiol. 2003 Nov;90(5-6):575-80. Epub 2003 Aug 16.

69.  Kostka T, Patricot MC, Mathian B, Lacour JR, Bonnefoy M. Anabolic and catabolic hormonal responses to experimental two-set low-volume resistance exercise in sedentary and active elderly people. Aging Clin Exp Res. 2003 Apr;15(2):123-30.

70.  Brenes GA, Williamson JD, Messier SP, Rejeski WJ, Pahor M, Ip E, Penninx BW. Treatment of minor depression in older adults: A pilot study comparing sertraline and exercise. Aging Ment Health. 2007 Jan;11(1):61-8.

Emotional Freedom Technique. 2007 Jan 11. http://www.emofree.com/.